18F-sodium fluoride (NaF) is a readily available radiotracer that has shown great potential to study bone metabolism associated with osseous diseases such as osteoporosis. We analyzed PET/CT and MRI data to study the effects of bone volume fraction and marrow distribution on the uptake of NaF in the proximal femur. Our data showed that the mean standardized uptake (SUVmean) decreased with age and became more significant when local adjustments for bone and bone marrow were taken into account. We foresee the importance of high-resolution microstructural bone MRI for the partial volume correction of PET data for accurate quantification bone metabolism.
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