This study presents both an analysis pipeline for measuring diaphragmatic motion from cine MRI data, and the application of this image processing technique to investigate exploratory MRI endpoints of respiratory function in both healthy controls and non-ambulant DMD boys. Cine-derived metrics of diaphragm motility and contractility correlated with sitting spirometry-derived forced vital capacity, and showed relationships with disease progression surrogates of age and months non-ambulatory, as well as a longitudinal change over 12 months. Longitudinal changes were not seen in spirometry measures.
This abstract and the presentation materials are available to members only; a login is required.