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Abstract #1558

Quantitative multiparametric relaxation time mapping of experimental model of osteoarthritis in the equine

Mikko Johannes Nissi1,2, Abdul Wahed Kajabi3, Juuso Ketola3, Jaakko K Sarin1, Victor Casula3,4, Irina A. D. Mancini5, Harold Brommer5, René P van Weeren5, Jos Malda5,6, Juha Töyräs1, and Miika T Nieminen3,4,7

1Department of Applied Physics, University of Eastern Finland, Kuopio, Finland, 2Department of Diagnostic Radiology, Kuopio University Hospital, Kuopio, Finland, 3Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland, 4Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland, 5Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands, 6Department of Orthopaedics, University Medical Center Utrecht, Utrecht, Netherlands, 7Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland

In this study, sensitivity of several quantitative MRI (qMRI) parameters, namely T1, T2, continuous wave (CW) T1ρ, adiabatic T1ρ, adiabatic T2ρ and TRAFF were investigated for their sensitivity to secondary degenerative changes in equine articular cartilage specimens (n=13+6 lesions and controls, respectively) due to presence of surgically induced lesions in the adjacent tissue. Significant differences in relaxation times between ROIs in the secondary affected, lesion repair tissue and adjacent controls area or control animals were detected. The findings suggest that properties of cartilage are altered due to the presence of a lesion in adjacent tissue.

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