Synopsis: The agreement and associations of T1p values with different spin lock frequencies were evaluated for the detection of radiographic knee OA and association with patient-reported outcomes. Analyses were performed in vivo at 3T MRI. Significant differences were identified between FSL 500 Hz, 3 TSL and T2 in all knee compartments and between FSL 700 Hz, 3 TSL and FSL 500 Hz, 3 TSL. While similar behavior was observed in distinguishing radiographic OA, T1ρ computed at higher FLS (700 Hz) and R2-R1ρ 700Hz demonstrated a better association with patient-reported outcomes.
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