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Abstract #1541

Correlation time mapping of articular cartilage degeneration in equine model

Abdul Wahed Kajabi1,2, Mikko J. Nissi3,4, Juuso Ketola2, Jaakko K. Sarin3, Victor Casula1,2, Juha Töyräs3,4, René Van Weeren5, Harold Brommer5, Jos Malda5,6, Irina A.D. Mancini5, Matti Hanni1,2,7, and Miika T. Nieminen1,2,7

1Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland, 2Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland, 3Department of Applied Physics, University of Eestern Finland, Kuopio, Finland, 4Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland, 5Department of Equine Sciences, Utrecht University, Netherlands, 6Department of Orthopaedics, University Medical Center Utrecht, Netherlands, 7Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland

Correlation time mapping was utilized to study structural alterations in articular cartilage of the femoral trochlea harvested from skeletally mature equines. Samples originated from a study in which surgically created lesions in the lateral trochlear ridge of the femur were filled with different materials and were left to heal for 12 months. Correlation time maps of the cartilage or repaired tissues were obtained from fitting T1ρ relaxation dispersion data. The correlation times of the repair tissue from the lesion site and tissue next to the lesion site were significantly shorter than the correlation times in a location distant from the lesion, indicating gradual degenerative changes observed in early osteoarthritis.

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Abstract