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Abstract #1371

Reproducibility Study of Direct and Non-Linear Inversion High-Resolution Magnetic Resonance Elastography (MRE) of the Hippocampus

Lucy V Hiscox1,2, Mike Perrins2, Curtis L Johnson3, Matt DJ McGarry4,5, Eric Barnhill6, John Huston III7, Ingolf Sack6, Jürgen Braun6, Edwin JR van Beek2, John M Starr1, and Neil Roberts2

1Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, United Kingdom, 2Clinical Research Imaging Centre, University of Edinburgh, Edinburgh, United Kingdom, 3Department of Biomedical Engineering, University of Delaware, 4Thayer School of Engineering, Dartmouth College, 5Department of Biomedical Engineering, Columbia University, 6Institute for Medical Informatics, Charité Universitätsmedizin Berlin, 7Department of Radiology, Mayo Clinic

Certain neurological disorders may not be detected with current clinical imaging modalities. Magnetic Resonance Elastography (MRE) combines acoustics with MRI to provide maps of tissue mechanical properties and may be sensitive to subtle tissue pathologies. Two published approaches for performing high-resolution MRE (so-called Direct Inversion and Non-Linear inversion) were applied to enable comparison of test-retest reproducibility of the hippocampus. Intraclass correlation coefficient found DI and NLI to display fair (0.42) and excellent (0.95) reproducibility, respectively, for measuring the magnitude of the complex shear modulus |G*|. Future work will assess the relative magnitude of technical and biological variance including both sex and ageing effects.

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