Preliminary Clinical Experience with FDG-PET/MRI in Plasma Cell Dyscrasias
Tyler J Fraum1, Daniel R Ludwig1, Ephraim E Parent1, Farrokh Dehdashti1, Michelle Miller-Thomas1, Monica Shokeen1, Keith Stockerl-Goldstein1, Ravi Vij1, and Kathryn J Fowler 1
1Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, United States
Multiple myeloma (MM) is an attractive target for FDG-PET/MRI, given the inherent limitations of both MRI and FDG-PET/CT when obtained separately. We performed FDG-PET/MR in a total of 36 patients with clinical diagnoses of a plasma cell dyscrasia (PCD), including a subset that underwent PET/CT and PET/MRI on the same day as part of a research protocol. FDG-PET/MRI was feasible for both the initial staging and subsequent treatment response assessment of PCDs and provided additional useful information compared with PET/CT. Sagittal T1-weighted images of the spine should be incorporated into standard protocols to improve spinal lesion detection.
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