We compared resting state (RS) functional connectivity (FC) of five thalamic sub-regions (frontal, motor, post-central, occipital and temporal) between patients with multiple sclerosis (MS) and healthy controls. There was an overall increase of intra- and inter-thalamic RS FC for almost all thalamic sub-regions, apart from the temporal thalamic sub-region, which showed reduced intra-thalamic RS FC and higher RS FC with the fronto-parietal somatomotor cortex. Compared to cognitively preserved, cognitively impaired MS patients had lower RS FC between thalamic sub-regions and caudate nucleus, anterior cingulate cortex, as well as higher RS FC between thalamic sub-regions and several temporal areas.
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