Abstract #1207

Assessing the cellular distribution of iron in deep gray matter based on R2* and Quantitative Susceptibility Mapping (QSM) - Application to healthy controls and patients with Multiple Sclerosis (MS)

Yanis Taege¹, Robert Zivadinov^1,2, Jannis Hanspach¹, Jesper Hagemeier¹, Michael G Dwyer¹, Balint P Sule¹, Nicola Bertolino¹, Dhaval Shah¹, Dejan Jakimovski¹, Niels P Bergsland^1,3, Bianca Weinstock-Guttman⁴, and Ferdinand Schweser^1,2

¹Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States, ²MRI Clinical and Translational Research Center, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States, ³MR Research Laboratory, IRCCS, Don Gnocchi Foundation ONLUS, Milan, Italy, ⁴BairdMS Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY, United States

This work introduces a clinically applicable technique to assess the cellular distribution of iron based on R₂* and Quantitative Susceptibility Mapping (QSM). The method was applied to 68 MS patients and 29 controls, showing significant differences in the cellular iron distribution with age and disability.

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