Abstract #1192

Efficient IVIM of the Liver using Convex Optimized Diffusion Encoding Waveforms With Variable Flow Encoding Strengths

Kévin Moulin¹, Eric Aliotta^1,2, and Daniel B. Ennis^1,2

¹Department of Radiological Sciences, University of California, Los Angeles, CA, United States, ²Biomedical Physics IDP, University of California, Los Angeles, CA, United States

Accounting for the flow encoding strength α in addition to the b-value in the Intra-Voxel Incoherent Motion (IVIM) technique enables robust perfusion estimation. However, this approach still requires long scan times and α is dependent on both the diffusion encoding waveform and the b-value. In this study, waveforms were generated using the convex diffusion encoding (CODE) framework and led to a range of α for a given b-value. By sampling of flow- and diffusion-encoding space, capillary blood velocity (V_b), perfusion fraction (f) and true diffusion (D) was estimated with higher precision without any cost in time compared to conventional IVIM.

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