Abstract #1186

Quantitative ventilation-perfusion imaging using co-registered hyperpolarized gas and contrast enhanced 1H perfusion MRI

Paul John Clifford Hughes¹, Bilal Tahir^1,2, Felix C. Horn¹, Alberto Biancardi¹, Rob Ireland², Helen Marshall¹, and Jim Wild^1,3

¹POLARIS, Academic Unit of Radiology, University of Sheffield, Sheffield, United Kingdom, ²Academic Unit of Clinical Oncology, University of Sheffield, Sheffield, United Kingdom, ³Insigneo Institute for in silico Medicine, Sheffield, United Kingdom

Analysis of the matching of ventilation and perfusion using MRI is an important area of research in the pulmonary MRI community. This work presents a quantitative method of voxelwise analysis of ventilation from hyperpolarized gas MRI and perfusion from dynamic contrast enhanced ¹H MRI. The method developed allows for direct comparison of ventilation and perfusion including global measurements of ventilated and perfused volume.

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