Abstract #1163

Hybrid MR-PET of Brain Tumours with amino acid-PET and Amide Proton Transfer MRI

Nuno André da Silva¹, Philipp Lohmann¹, James Fairney^2,3, Arthur W. Magill¹, Ana-Maria Oros-Peusquens¹, Chang-Hoon Choi¹, Rüdiger Stirnberg ^1,4, Xavier Golay^2,3, Karl-Josef Langen^1,5,6, and N Jon Shah^1,7,8

¹Institute of Neuroscience and Medicine - 4, Forschungszentrum Jülich, Jülich, Germany, ²Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, ³Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom, ⁴German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, ⁵Jülich Aachen Research Alliance (JARA), Section JARA Brain, Aachen, Germany, ⁶Department of Nuclear Medicine, RWTH University of Aachen, Aachen, Germany, ⁷Department of Neurology, Faculty of Medicine, RWTH Aachen University, JARA, Aachen, Germany, ⁸Department of Electrical and Computer Systems Engineering, and Monash Biomedical Imaging, School of Psychological Sciences, Monash University, Melbourne, Australia

Information on amino acid metabolism has become an important component of the diagnostic and prognostic precision in the investigation of brain tumours. Both MRI and PET present methods to obtain amino acid weighted images, such as chemical exchange saturation transfer (CEST) or O-(2-18F- fluoroethyl)-L-tyrosine (FET), respectively. In this work, FET-PET and CEST imaging of brain tumours is investigated using hybrid MR-PET in 8 patients with brain tumours. The results suggest that the tumour-to-brain ratio of magnetization transfer ratio asymmetry (MTR_asym) encodes different information than that from FET PET.

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