Abstract #1159

GPR88 signatures on the reward resting state brain networks after alcohol exposure in mice

Tanzil Mahmud Arefin^1,2,3, Sami Ben Hamida^3,4, Thomas Bienert¹, Thiago Marques De Melo^1,5, Hsu-Lei Lee¹, Jürgen Hennig¹, Dominik von Elverfeldt¹, Brigitte Kieffer^3,4, and Laura-Adela Harsan^1,6,7

¹Advanced Molecular Imaging Center, Medical Physics, Department of Radiology, University Medical Center Freiburg, Freiburg, Germany, ²Faculty of Biology, University of Freiburg, Freiburg, Germany, ³Department of Translational Medicine and Neurogenetics, Institute of Genetics and Molecular and Cellular Biology (IGBMC), Illkirch-Graffenstaden, Strasbourg, France, ⁴Department of Psychiatry, Douglas Hospital Research Center, School of Medicine, McGill University, Montreal, QC, Canada, ⁵Spemann Graduate School of Biology and Medicine, University of Freiburg, Germany, ⁶Department of Biophysics and Nuclear Medicine, University Hospital Strasbourg, Strasbourg, France, ⁷Laboratory of Engineering, Informatics and Imaging, University of Strasbourg, Strasbourg, France

Identifying the genetic and molecular factors regulating the development and the dynamics of brain functional connectivity (FC) networks in health and disease is important to develop novel therapeutic strategies. Resting state functional magnetic resonance imaging (rsfMRI) can reveal the FC remodeling in psychiatric disorders and drug addiction. Emerging studies suggest that neuronal responses to alcohol involve several G protein-coupled receptors (GPCR)-mediated signaling pathways, inducing short-term to long-term changes in behavioral and neuronal plasticity. This study investigates the role of GPR88 in the acquisition and development of alcohol dependence and unravels the rsFC modifications underpinning this processes in the mouse brain.

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