Abstract #1146

Novel NMR biomarkers characterizing human knee synovial fluid after ACL-injuries: correlation with immunoassay and longitudinal cartilage MR T1ρ and T2 imaging

Kaipin Xu¹, Keiko Amano¹, Matthew Tanaka¹, Subramaniam Sukumar¹, John Kurhanewicz¹, Virginia Kraus², Benjamin Ma¹, and Xiaojuan Li¹

¹University of California, San Francisco, San Francisco, CA, United States, ²Duke University, Durham, NC, United States

Subjects with acute anterior cruciate ligament (ACL) injury have a high risk of developing post-traumatic osteoarthritis (PTOA) even after ACL reconstruction. To identify novel NMR biomarkers of synovial fluid that may predict cartilage degeneration after acute injury and to develop potential preventative strategies for PTOA, human knee synovial fluid harvested from 25 anterior cruciate ligament (ACL) injured subjects were studied using high resolution magic angle spinning (HR-MAS) NMR spectroscopy and correlated to immunoassay and longitudinal cartilage MR T1ρ and T2 imaging.

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