Abstract #1127

Panning for Salt: One Millimeter Resolution In Vivo Sodium MRI of the Human Eye at 7.0 Tesla Using a Six Channel Transceiver Array

Daniel Wenz¹, Oliver Weinberger¹, Andre Kuehne², Helmar Waiczies², Armin Nagel^3,4, Celal Oezerdem¹, Till Huelnhagen¹, Darius Lysiak², Lukas Winter¹, Oliver Stachs⁵, Soenke Langner⁶, Erdmann Seeliger⁷, Bert Flemming⁷, and Thoralf Niendorf^1,8

¹Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany, ²MRI.TOOLS GmbH, Berlin, Germany, ³Institute of Radiology, University Hospital Erlangen, Erlangen, Germany, ⁴Division of Medical Physics in Radiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany, ⁵Department of Ophthalmology, University of Rostock, Rostock, Germany, ⁶Institute for Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany, ⁷Institute for Physiology, Charité University Medicine, Berlin, Germany, ⁸Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine in the Helmholtz Association

Sodium quantification in the eye may be a valuable aid not only in diagnosis of ocular diseases, but in follow-up after proton therapy of eye tumors. Recognizing this potential, this is the first report on high fidelity in vivo sodium (²³Na) MRI of the human eye at 7.0 Tesla. To achieve this goal a six-channel ²³Na transceiver array was designed, simulated, built and validated in phantoms. The in vivo studies demonstrated the feasibility of 1 mm isotropic spatial resolution ²³Na MRI of the eye and provided encouragement for clinical studies.

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