Abstract #1070

Multinuclear in vivo MR spectroscopy at 7T reveals differences in liver and muscle metabolism in NAFLD patients and healthy controls

Martin Gajdošík^1,2, Sabina Smajiš², Christian Kienbacher³, Lorenz Pfleger^1,2, Anton Luger², Siegfried Trattnig^1,4, Michael Trauner³, Michael Krebs², and Martin Krššák^1,2

¹High-field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ²Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria, ³Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria, ⁴Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria

Recent developments at 7T allowed for qualitative assessment of the hepatic lipids, faster measurement of glycogen and ATP turnover. Improved spectral resolution also enabled better separation and quantitation of hepatic metabolites. The aim of the study was to employ the advanced methods of multinuclear in vivo MR spectroscopy at 7T in the liver and muscles in non-alcoholic fatty liver disease (NAFLD) patients and healthy controls. Static and dynamic multinuclear MRS data, supported by mixed meal test and euglycemic-hyperinsulinemic clamp study, showed metabolic changes and disturbed interorgan crosstalk in NAFLD patients.

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