Abstract #1061

Metabolite cycled semi-LASER and STEAM at 9.4T. Comparison and in vivo results.

Ioannis-Angelos Giapitzakis^1,2, Tingting Shao¹, Nikolai Avdievitch¹, Nicole Fichtner^3,4, Ralf Mekle⁵, Roland Kreis ³, and Anke Henning^1,6

¹High Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, ²Graduate School of Neural and Behavioural Sciences, Tuebingen, Germany, ³Departments of Radiology and Clinical Research, University Bern, Bern, Switzerland, ⁴Institute for Biomedical Engineering, UZH and ETH Zurich, Zurich, Switzerland, ⁵Center for Stroke Research Berlin (CSB), Charité Universitätsmedizin Berlin, Berlin, Germany, ⁶Institute of Physics, Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany

The purpose of this study was the development of two new localization schemes for ultra high field (UHF) spectroscopic applications while utilizing the advantages of the Metabolite Cycling (MC) technique. In particular, a semi-adiabatic asymmetric pulse optimized for MC at 9.4T was incorporated into STEAM and semi-LASER localization schemes. In this study, these two new sequences along with the appropriate hardware setup were used to acquire in vivo 1H MRS data from the occipital lobe of the human brain and compare the corresponding results. In addition, the effect of frequency and phase correction based on the MC water spectra on data quality was investigated.

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