GlucoCEST generates a contrast that is sensitive to glucose uptake and metabolism. While previously shown with tumor models, a distinct glucose metabolism is also characteristic of pregnancy. This study explores the potential of glucoCEST under this condition. Glucose was administered to pregnant mice by gavage in a manner akin to that used in human pregnancy-induced diabetes tests, and subsequently monitored in-vivo by glucoCEST at 21.1T. Distinct differences were apparent upon instituting glucose, with organ-specific glucoCEST contrast exceeding 50-70%. Notable imaging differences were noted between dame and fetuses upon glucose gavage, as well as between pregnant and non-pregnant animals.
This abstract and the presentation materials are available to members only; a login is required.