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Abstract #0999

Magneto-Caloric Materials as Tunable and Switchable Labels for MRI

Mladen Barbic1, Tim D Harris1, Stephen Dodd2, H Douglas Morris3, Alan P Koretsky2, Barbara Marcheschi4, Alan Huston4, and Neil R Dilley5

1Applied Physics and Instrumentation Group, HHMI-Janelia Research Campus, Ashburn, VA, United States, 2Laboratory of Functional and Molecular Imaging, NIH/NINDS, Bethesda, MD, United States, 3NIH Mouse Imaging Facility, NIH/NINDS, Bethesda, MD, United States, 4Code 5611, Optical Sciences Division, Naval Research Laboratory, Washington, DC, United States, 5Quantum Design, Inc., San Diego, CA, United States

We present the case for the use of magneto-caloric materials as tunable and switchable labels for MRI. Sharp magnetic phase transitions these materials have at typical physiological temperatures and in the presence of the large DC magnetic field values associated with MRI machines make them uniquely suitable for the development of novel MRI contrast agents. We present physical and MRI measurements of a prototypical magneto-caloric material Iron-Rhodium (FeRh) that clearly demonstrate the MR image contrast changes due to the temperature tunable magnetic state of the material in the MRI compatible magnetic field range and physiologically relevant temperature range.

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