Abstract #0989

MR Elastography and Perfusion MRI for the Early Assessment of Treatment Response in Soft Tissue Sarcomas

Kay Pepin¹, Roger Grimm², Soudabeh Kargar³, Sarah James¹, Matthew Howe², Karen Fritchie⁴, Matthew Frick², Doris Wenger², Richard Ehman², Nadia Laack¹, Michael Herman¹, and Deanna Pafundi¹

¹Radiation Oncology, Mayo Clinic, Rochester, MN, United States, ²Radiology, Mayo Clinic, Rochester, MN, United States, ³Mayo Graduate School, Mayo Clinic, Rochester, MN, United States, ⁴Pathology, Mayo Clinic, Rochester, MN, United States

Advanced imaging is a critical component in the development of patient-specific and novel treatment strategies, and the non-invasive evaluation of early response in sarcomas. Our central hypothesis is that changes in sarcoma stiffness quantified with MRE and perfusion with DCE-MRI throughout therapy can predict response. Soft tissue sarcomas are a rare malignancy arising in a wide range of anatomic locations. Anatomy-specific imaging protocols were developed to evaluate soft tissue sarcomas in 9 patients. In 3 patients, we investigated the feasibility to assess response to radiation therapy and observed a decrease in parameters related to tumor stiffness and perfusion metrics.

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