Meeting Banner
Abstract #0949

Reproducibility of ADC measures by Breast DWI: Results of the ACRIN 6698 Trial

David C Newitt1, Zheng Zhang2, Jessica Gibbs1, Savannah C Partridge3, Thomas L Chenevert4, Patrick J Bolan5, Mark Rosen6, Helga Marques2, and Nola Hylton1

1Radiology and Biomedical Imaging, University of California, San Francisco, CA, United States, 2Biostatistics, Brown University, Providence, RI, United States, 3Radiology, University of Washington, Seattle, WA, United States, 4Radiology, University of Michigan Health System, Ann Arbor, MI, United States, 5Radiology, University of Minnesota, Minneapolis, MN, United States, 6University of Pennsylvania, Philadelphia, PA, United States

The multi-institutional ACRIN 6698 trial investigates quantitative diffusion weighted imaging (DWI) for assessment of breast cancer response to treatment. A secondary aim is to perform a test/retest study to evaluate reproducibility of ADC measures. In a subset of 91 subjects, DWI was acquired twice in the same exam, before and after patient repositioning. Tumor ADC was measured separately for each acquisition. 80% of cases were found analyzable by a standardized quality-control procedure. Reproducibility of ADC was excellent, with intraclass correlation coefficient of 0.97 (95%CI 0.95, 0.98) and agreement index of 0.83 (95%CI 0.76,0.87). Results were similar for subgroups by field strength or study visit.

This abstract and the presentation materials are available to members only; a login is required.

Join Here

Abstract Presentation Video