Abstract #0947

Quantitative non-Gaussian diffusion and IVIM MRI: Correlation between synthetic parameters and breast cancer biomarkers

Mami Iima^1,2, Masako Kataoka¹, Shotaro Kanao¹, Natsuko Onishi¹, Makiko Kawai¹, Akane Ohashi¹, Rena Sakaguchi¹, Ayami Ohno Kishimoto¹, Masakazu Toi³, and Kaori Togashi¹

¹Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ²Hakubi Center for Advanced Research, Kyoto University, Kyoto, Japan, ³Department of Breast Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan

The association of IVIM/non-Gaussian diffusion MRI parameters with biological feature or subtypes in breast cancer was evaluated. For 144 malignant lesions, IVIM (fIVIM,D*) and non-Gaussian diffusion (ADCo,K) parameters were estimated from DWI series with 16 b values (0-2500sec/mm²), as well as syntheticADC (sADC) (b=200,1500sec/mm²) and ADC (b=0,800sec/mm²). sADC and K values were significantly different between ER,PgR,andHer2 status (p<0.05,0.01,0.05 for sADC and p<0.05,0.05,0.05 for K). There was a significant difference of ADC values between PgRandHer2 status (p<0.05,0.01). No significant difference of IVIM was found. ADCo, sADC, and ADC showed the statistical significance in differentiating subtypes of breast cancer (p<0.05,<0.01,<0.01).

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