Abstract #0929

Characterisation of in-vivo and ex-vivo cardiac Diffusion Tensor Imaging scalar measures of cardiac microstructure in healthy swine

Sonia Nielles-Vallespin^1,2, Pedro F Ferreira², Andrew D Scott², Ranil de Silva², Philip Kilner², Daniel B Ennis³, Dudley J Pennell², David N Firmin², and Andrew E Arai¹

¹NHLBI, NIH, Bethesda, MD, United States, ²Royal Brompton Hospital, Imperial College of London, London, United Kingdom, ³Department of Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States

In-vivo cDTI was performed at several cardiac phases in healthy swine (N=16), followed by ex-vivo cDTI in two contractile states. The three eigenvalues (L1, L2, L3), MD, FA and Mode were compared. All trends between in-vivo diastole and systole matched those between ex-vivo relaxed and contracted states, except for MD, which decreased ~10% in-vivo from diastole to systole, with no significant differences ex-vivo between relaxed and contracted states. These results provide a useful baseline for future preclinical studies with cardiac disease models, and might contribute towards formulating a strain correction model that accounts for the microstructural constraints and deformations of the myocardium.

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