Metabolic variability in a brief status epilepticus model

This study uses short echo MR spectroscopy (TE 10ms) to study the metabolic changes seen in a status epilepticus kainate rodent model. Applied with a brief period (45min) of seizures, a hierarchical cluster analysis is performed on the spectroscopic changes measured 3days after the status injury. These data displayed a bimodal distribution characterizing two groups of animals, “more” or “less” injured. The classification persists into a repeat MRS measurement performed at 3wk, with the less injured group being able to recover; the more injured group did not recover well. Finally, this classification was consistent with Nissl based histological analysis.