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Abstract #0868

Validation of VERDICT MRI using fresh and fixed prostate specimens with aligned histological slices

Colleen Bailey1, Roger M Bourne2, Bernard Siow3,4, Edward W Johnston5, Hayley Pye6,7, Susan Heavey6,7, Thomy Mertzanidou1, Hayley Whitaker6, Alexander Freeman8, Dominic Patel8, Greg Shaw6,7, Ashwin Sridhar6,7, Shonit Punwani5, David J Hawkes1, Daniel C Alexander1, and Eleftheria Panagiotaki1

1Centre for Medical Image Computing, University College London, London, United Kingdom, 2Discipline of Medical Radiation Sciences, University of Syney, Sydney, Australia, 3Centre for Advianced Biomedical Imaging, University College London, London, United Kingdom, 4Imaging, Francis Crick Insitute, London, United Kingdom, 5Centre for Medical Imaging, University College London, London, United Kingdom, 6Division of Surgery and Interventional Science, University College London, London, United Kingdom, 7Department of Urology, University College London Hospitals, London, United Kingdom, 8Department of Research Pathology, University College London, London, United Kingdom

This study provides the first step in validating the VERDICT diffusion model of tissue microstructure by examining the effects of fixation on tissue microstructure and comparing VERDICT parameter maps to histological features. Fresh and fixed parameter maps showed similar spatial trends: fixation decreased the extracellular volume fraction parameter and decreased the cell radius parameter slightly, consistent with water efflux. Intracellular volume fraction was lower in regions with lower cellularity, such as the peripheral zone, and directions of diffusion anisotropy corresponded with collagen and smooth muscle orientation patterns in the stroma.

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Abstract