Abstract #0861

Clinical Translation of Tumor Acidosis Measurements with AcidoCEST MRI

Kyle M. Jones¹, Edward A. Randtke², Eriko Yoshimaru³, Christine M. Howison², Pavani Chalasani⁴, Robert R Klein⁴, Setsuko K. Chambers³, Phillip H. Kuo², and Mark D. Pagel²

¹Biomedical Engineering, University of Arizona, Tucson, AZ, United States, ²Medical Imaging, University of Arizona, Tucson, AZ, United States, ³University of Arizona Cancer Center, University of Arizona, Tucson, AZ, United States, ⁴Medicine, University of Arizona, Tucson, AZ, United States

We optimized acidoCEST MRI, a method that measures extracellular pH (pHe), and translated this method for clinical imaging. We fit CEST spectra with the Bloch equations modified to include the direct estimation of pH, and generated parametric maps of tumor pHe in the SKOV3 tumor model, a patient with high grade invasive ductal breast carcinoma, and a patient with metastatic ovarian cancer. AcidoCEST MRI successfully measured a pH 6.58 in a tumor of the patient with metastatic ovarian cancer. The primary breast tumor failed to accumulate sufficient agent to generate pHe measurements.

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