Apparent diffusion coefficient (ADC) and diffusion kurtosis are both sensitive markers to ischemic brain injury. We investigated the diffusion time (td)-dependency of ADC and kurtosis at nine td’s ranging from 2.5 to 60 ms in a mouse model of neonatal hypoxic-ischemic injury. In the hippocampus, ADCs showed a monotonous decrease with increasing td, whereas kurtosis reached its maximum at td of 5-10 ms and decreased for longer td’s . At the shortest td in this study, we found significant increased kurtosis in the edema region but no significant reduction in diffusivity, suggesting their different sensitivities to microstructural changes after ischemic injury.
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