Abstract #0827

Functional lung MRI using matrix pencil decomposition and N2 multiple-breath washout measurements in cystic fibrosis

Grzegorz Bauman^1,2, Sylvia Nyilas^3,4, Orso Pusterla^1,2, Tanja Haas¹, Michael Ith⁵, Bernd Jung⁵, Carmen Casaulta³, Gregor Sommer⁶, Enno Stranzinger⁵, Urs Frey⁴, Philipp Latzin^3,4, and Oliver Bieri^1,2

¹Division of Radiological Physics, Department of Radiology, University of Basel Hospital, Basel, Switzerland, ²Department of Biomedical Engineering, University of Basel, Basel, Switzerland, ³Division of Respiratory Medicine, Department of Pediatrics, University Children's Hospital of Bern, Bern, Switzerland, ⁴Department of Pediatric Pneumology, University Children's Hospital Basel (UKBB), Basel, Switzerland, ⁵University Institute for Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, Bern, Switzerland, ⁶Department of Radiology, University of Basel Hospital, Basel, Switzerland

This study examines a correlation between the functional lung MRI using matrix pencil decomposition and lung function tests in patients with cystic fibrosis. A strong correlation between the global ventilation inhomogeneity index (LCI) from multiple breath washout and ventilation/perfusion impairment in the lung determined by functional MRI is observed. The results of our study support the potential of functional MRI as a diagnostic tool in monitoring disease progression in cystic fibrosis.

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