Quantitative Volumetric Histogram Analysis of Diffusion-weighted Magnetic Resonance Imaging: An Initial Experience of Solid Renal Cell Carcinoma with Different Prognosis

To evaluate the value of quantitative volumetric ADC histogram analysis for differentiation of clear cell RCC (ccRCC) from papillary RCC (pRCC) and chromophobe RCC (chRCC) which having different prognosis. Differences of ADC histogram parameters between better prognosis group and worse prognosis group were compared. There were significant differences on ADC_mean, ADC_median, ADC_10%, ADC_25%, ADC_75%, ADC_90% and skewness between these two different prognosis groups and the ADC_10% showed the best diagnostic value. Therefore, quantitative volumetric ADC histogram analysis can be considered a useful and noninvasive method to help distinguish three subtypes renal cell carcinomas which having different prognosis.