Abstract #0811

Novel Functional Brain Development Patterns during Infancy Revealed through the Application of Functionally Derived Brain Parcellations

Feng Shi¹, Andrew P Salzwedel¹, Weili Lin², John H Gilmore³, and Wei Gao¹

¹Biomedical Imaging Research Institute, Cedars Sinai Medical Center, Los Angeles, CA, United States, ²Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ³Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States

Signal heterogeneity within the predefined regions of interest (ROIs) may confound the functional connectivity estimation. In this study, we generate brain parcellations for neonate, 1-year, and 2-year-old infants, respectively, and use them to reveal potential novel functional developmental patterns. Our results show the progression of local functional specialization during early brain development. Moreover, different patterns of hub distributions are observed using different functional parcellation schemes suggesting the importance of selecting appropriate functionally-derived brain parcellations in characterizing infant whole brain connectivity pattern.

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