Abstract #0788

Prevalence of diffusely abnormal white matter in individuals with clinically isolated syndromes suggestive of multiple sclerosis

Cornelia Laule^1,2,3, Jimmy Lee¹, Guojun Zhao^4,5, Rick White⁶, Irene M. Vavasour¹, Andrew Riddehough^4,5, Anthony L. Traboulsee^4,5, Luanne Metz⁷, and David K.B. Li^1,4,5

¹Radiology, University of British Columbia, Vancouver, BC, Canada, ²Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada, ³International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, BC, Canada, ⁴Medicine (Neurology), University of British Columbia, Vancouver, BC, Canada, ⁵MS/MRI Research Group, University of British Columbia, Vancouver, BC, Canada, ⁶Statistics, University of British Columbia, Vancouver, BC, Canada, ⁷Medicine, University of Calgary, Calgary, AB, Canada

Diffusely abnormal white matter (DAWM) is present in individuals with clinically isolated syndromes (CIS) suggestive of multiple sclerosis (MS) at a similar frequency as seen in definite MS. CIS subjects with DAWM showed reduced brain volume and greater lesion load, both of which are known to correlate with clinical disability and progression. DAWM may have prognostic importance in CIS so examining its impact on conversion to MS, future disability and progression is warranted.

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