Abstract #0720

Mapping of cerebral cortical microstructure characterized by non-Gaussian water diffusion in aging

Qinmu Peng^1,2, King Kevin^3,4, Minhui Ouyang¹, Hanzhang Lu⁵, and Hao Huang^1,2

¹Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, United States, ²Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, ³Department of Imaging, Huntington Medical Research Institutes, ⁴Department of Radiology, University of Texas Southwestern Medical Center, ⁵Department of Radiology, Johns Hopkins University

The cellular and molecular processes inside the cerebral cortex play a critical role in aging and neurodegenerative disorders. The microstructural changes associated to these cortical processes can be assessed with multi-shell diffusion MRI. Here, we aimed to accurately quantify the regional cortical microstructural changes of the aging brains. Multi-shell diffusion MRI was acquired to measure mean kurtosis (MK) derived from DKI at the center of the cerebral cortical layer for specific cortical regions. Significant MK decreases were found in the primary somatosensory regions, but not in prefrontal and visual regions, suggesting differentiated aging processes in different cortical regions.

This abstract and the presentation materials are available to members only; a login is required.

Join Here