Abstract #0710

Brain volume loss in glioblastoma patients following photon and proton radiochemotherapy

Jan Petr¹, Frank Hofheinz¹, Andreas Gommlich^2,3,4, Felix Raschke², Esther Troost^2,3,5,6,7, Bettina Beuthien-Baumann^1,8, Annekatrin Seidlitz^2,5,6,7, Ivan Platzek⁹, Michael Baumann^2,3,5,6,7, Mechthild Krause^2,3,5,6,7, and Jörg van den Hoff^1,8

¹PET center, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany, ²OncoRay – National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Dresden, Germany, ³Institute of Radiooncology, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany, ⁴NCT - National Center for Tumor Disease, Dresden, Germany, ⁵Department of Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany, ⁶German Cancer Consortium (DKTK), Dresden, Germany, ⁷German Cancer Research Center (DKFZ), Heidelberg, Germany, ⁸Department of Nuclear Medicine, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany, ⁹Department of Radiology, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany

Gray matter (GM) atrophy in healthy brain tissue following radiochemotherapy was shown in brain-tumor patients in several studies. Here, we aimed to study GM and white matter (WM) changes in glioblastoma patients undergoing photon (n=43) and proton (n=12) radiochemotherapy. In photon-therapy patients, a statistically significant decrease of both GM (~2%) and WM (1.3-2.3%) volume was found with a positive influence of the RT-dose on the GM volume loss. In proton-therapy patients, no significant changes in GM and WM volumes were observed after therapy. This indicates that the proton-therapy has the potential to reduce structural GM changes in healthy tissue.

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