The aim of this study was to investigate the cardiac induced volumetric strain differences between grey and white matter at 7T with DENSE in young, healthy volunteers, which may provide information on properties of the microvasculature. Increasing volumetric strain was seen in the systolic phase of the heart. The average strain in the grey matter was larger compared to white matter, but this was not significant. Measuring whole brain volumetric strain is feasible with DENSE at 7T, and has the potential to assess microvascular function (passive swelling over the cardiac cycle) in various brain areas.
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