Multi-timepoint ASL can be acquired with several methods; however, most of these methods have some confounding aspects, such as loss of temporal resolution or limited brain coverage. We combine Hadamard-8 time-encoded-pCASL with Look-Locker readout (4 phases×150ms) for a high temporal resolution; moreover, multiband-factor 4 is used for a time efficient acquisition manner enabling whole brain coverage. This combination of techniques results in 25 PLDs for 16 slices, which provides information about the inflow of labeled blood and tissue perfusion. These images have a temporal resolution of 150ms, whereas inflow of label is measured at 75ms resolution.
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