MR T1ρ is used to investigate biochemical changes in cartilage composition, but few studies have looked at its application in radiocarpal wrist cartilage. In this study, we assess 1-year changes in T1ρ following rheumatoid arthritis treatment and its relationship with changes in clinical disease activity scores and patient-reported outcomes. Changes between 1-year and baseline T1ρ values correlated significantly with disease activity score changes and approached significance with patient-reported outcome changes during the same period. Changes in T1ρ values at 3-months also correlated significantly with 1-year changes in metacarpophalangeal and wrist bone erosion volume measured with high-resolution peripheral quantitative CT (HR-pQCT).
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