Abstract #0630

Hyperpolarized [1,4-13C2]Fumarate is a probe of necrosis in myocardial infarction

Jack Julian James Jenkins Miller^1,2,3, Angus Zoen Lau^1,4, Giles McMullen-Klein¹, Andrew Lewis¹, Vicky Ball¹, Carolyn Carr¹, Ferdia Gallagher⁵, Damian John Tyler^1,2, and Marie Schroder⁶

¹Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, United Kingdom, ²Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, United Kingdom, ³Department of Physics, University of Oxford, Oxford, United Kingdom, ⁴Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, ⁵Department of Radiology, University of Cambridge, Cambridge, United Kingdom, ⁶MR Centret, Århus University Hospital, Skejby, Denmark

Previous work has shown that hyperpolarized [1,4-¹³C₂]fumarate is a probe of cellular necrosis. We demonstrate here that the ratio of cardiac hyperpolarized malate to fumarate is increased by a factor of $$$\sim$$$82 one day after cryoinduced myocardial infarction in rats, decreasing to an $$$\sim$$$30-fold increase one week after injury. We additionally image this injury with a novel spiral multiband pulse sequence. Hyperpolarized fumarate therefore forms a sensitive probe of myocardial injury in vivo, and could form a clinical monitor of cellular damage and necrosis after infarction.

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