Abstract #0628

Quantifying microstructure changes in a mouse brain tumour model following Temozolomide therapy with VERDICT MRI

Thomas A Roberts¹, Giulia Agliardi¹, Ben Hipwell¹, Angela D'Esposito¹, Andrada Ianus², James O Breen-Norris¹, Valerie Taylor¹, Mark F Lythgoe¹, Bernard Siow¹, Eleftheria Panagiotaki², Daniel C Alexander², and Simon Walker-Samuel¹

¹Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom, ²Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom

In this study, we use VERDICT (Vascular, Extracellular and Restricted Diffusion for Cytometry in Tumours) MRI to assess longitudinal changes in the microstructure of a mouse model of glioma (GL261), following treatment with Temozolomide, an alkylating chemotherapeutic agent. VERDICT estimates of cell radius and intracellular volume fraction decreased significantly at day-6 of therapy, relative to control animals, and in advance of changes in tumour volume and ADC. These changes were consistent with histological changes measured in the same tumours, and are likely to correspond to microstructural changes induced by apoptosis.

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