Evaluation of Approximation Method for B1+ Correction using Digital Reference Object in Prostate DCE-MRI
Xinran Zhong1,2, Holden Wu1,2, Krishna Nayak3, and Kyunghyun Sung1,2
1Department of Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, United States, 2Physics and Biology in Medicine IDP, University of California, Los Angeles, Los Angeles, CA, United States, 3Department of Electrical Engineering, University of Southern California, Los Angeles, CA, United States
A digital reference object (DRO) for prostate dynamic contrast-enhanced MRI application is created by modifying DRO created by the RRSNA Quantitative Imaging Biomarkers Alliance (QIBA). Our previously proposed approximation B1+ correction method for pharmacokinetic modeling was then tested on this DRO assuming B1+variation of 20%, considering practical considerations such as fitting method, arterial input function selection and noise level. The proposed approximation method introduced error is shown to be negligible compared to B1+ introduced error and noise introduced error.
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