Abstract #0619

Glial activation measured by [11C]-PBR28 PET correlates with 1H-MRS brain metabolites in amyotrophic lateral sclerosis

Eva-Maria Ratai^1,2, Mohamad J Alshikho^2,3, Nicole R. Zürcher^1,2, Marco L. Loggia¹, Paul Cernasov ³, Jennifer Fish³, Raghav Seth¹, Sabrina Paganoni^2,3, Bruce R. Rosen^1,2, Jacob M. Hooker^1,2, and Nazem Atassi^2,3

¹Radiology, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ²Harvard Medical School, ³Neurology, Neurological Clinical Research Institute (NCRI), A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States

The purpose of our study was to evaluate the relationship between glial activation assessed by [¹¹C]-PBR28 positron emission tomography, and neuronal integrity and gliosis/neuroinflammation measured by magnetic resonance spectroscopy in people with amyotrophic lateral sclerosis (ALS). Glial activation measured by increased [¹¹C]-PBR28 uptake correlated with increased levels of myo-Inositol/Creatine, a spectroscopic marker of gliosis/neuroinflammation in the brain stem and motor cortices. Furthermore, increased [¹¹C]-PBR28 uptake correlated with neuronal damage measured by decreased N-acetylaspartate/Creatine levels. To our knowledge, this is the first study to evaluate the relationship between glial activation, measured by [¹¹C]-PBR28 PET, and brain metabolites assessed by MRS.

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