Abstract #0612

Pharmacological arterial spin labeling reveals distinct mesocorticolimbic blood flow in Parkinson’s disease patients with compulsive reward-driven behaviors

Daniel Claassen¹, Adam Stark², Charis Spears², Kalen Petersen³, Scott Wylie², Nelleke van Wouwe², Robert Kessler⁴, David Zald⁵, and Manus J Donahue³

¹Neurology, Vanderbilt University Medical Center, Nashville, TN, United States, ²Neurology, Vanderbilt University Medical Center, ³Radiology, Vanderbilt University Medical Center, ⁴Radiology, University of Alabama at Birmingham, ⁵Psychology, Vanderbilt University Medical Center

The overall goal of this work is to apply pharmacological arterial spin labeling (ASL) to investigate fundamental hypotheses regarding the role of dopamine agonist (DAgonist) therapy in patients with Parkinson’s disease and impulse control behavior (ICB). Parkinson’s disease patients (n=35; age range=40-79 years; gender=23/12 males/females) receiving DAgonist therapy, with (n=17) and without (n=18) DAgonist-induced ICB were scanned at 3T using cerebral blood flow (CBF)-weighted pCASL MRI. Region-of-interest analyses revealed significantly increased bilateral ventral striatal (P<0.01) CBF in patients with ICB in the On- DAgonist state; voxel-wise analysis of CBF confirmed widespread DAgonist-induced CBF increases in mesolimbic, mesocortical, and midbrain regions.

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