Abstract #0596

MRI visualization of brain-like tissue formation following implantation of neural precursors into in cerebrospinal fluid

Nikorn Pothayee¹, Dragan Maric², Kathryn Sharer¹, Jung-Hwa Tao-Cheng ³, Stephen Dodd¹, Alec Calac¹, James Pickel⁴, and Alan Koretsky¹

¹Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States, ²Flow Cytometry Core Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States, ³Electron Microscopy Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States, ⁴Transgenic Core Facility, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States

Neural stem cell transplantation has been hailed as a promising approach for treatment of neurological diseases. While most in vivo studies have implanted cells into specific sites in brain tissue, little is known whether the cerebrospinal fluid (CSF) provides a permissive environment in cultivating tissue growth. Here, using MRI, we investigate whether early neural precursor cells could initiate a large-scale formation of new brain tissue in the CSF of adult rat.

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