Abstract #0568

CMRO2 Quantification in Human Brain with Direct 17O-MRI: Profile Likelihood Analysis for Optimization of Temporal Resolution

Dmitry Kurzhunov¹, Robert Borowiak^1,2,3, Ali Caglar Özen¹, and Michael Bock¹

¹Dept. of Radiology, Medical Physics, Medical Center – University of Freiburg, Freiburg, Germany, ²German Cancer Consortium (DKTK), Heidelberg, Germany, ³German Cancer Research Center (DKFZ), Heidelberg, Germany

In this study the temporal resolution of ¹⁷O-MRI protocols for quantification of the cerebral metabolic rate of oxygen consumption (CMRO₂) in human brain were optimized using the profile likelihood (PL) method. For this, retrospective analysis of the influence of temporal resolution on the CMRO₂ values and their PL-based confidence intervals (CI) was performed. Dynamic ¹⁷O-MRI was implemented with a 3D golden-angle radial acquisition during and after inhalation of ¹⁷O gas. The results showed that ¹⁷O-MRI data acquired at a temporal resolution 120≤Δt≤165 seconds gave identifiable CMRO₂ values of 0.82‑1.18/0.92‑1.42 µmol/g_tissue/min in WM/GM brain regions.

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