Abstract #0555

Dynamic Hyperpolarized 13C Metabolic Imaging of Patients with Brain Tumors

Ilwoo Park¹, Peder EZ Larson¹, Jeremy Gordon¹, Lucas Carvajal¹, Hsin-Yu Chen¹, Mark VanCriekinge¹, Robert Bok¹, Jason C Crane¹, Adam Elkhaled¹, Joanna Phillips², James B Slater¹, Marcus Ferrone³, John Kurhanewicz¹, Dan Vigneron¹, Susan Chang², and Sarah J Nelson¹

¹Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, ²Neurological Surgery, University of California San Francisco, San Francisco, CA, United States, ³Department of Clinical Pharmacy, University of California San Francisco, San Francisco, CA, United States

Dynamic ¹³C data were acquired following injection of hyperpolarized [1-¹³C]pyruvate from 3 patients previously diagnosed with glioblastoma. Pyruvate, lactate and bicarbonate signal with high SNR were detected in human brain. Lactate/Pyruvate appeared to be relatively high in the contra-lateral, normal appearing brain. In contrast, tumor regions produced higher Lactate/Bicarbonate than contra-lateral brain. The contrast-enhancing lesion of one patient, who underwent surgical resection shortly after ¹³C imaging due to suspected recurrence, produced a relatively low level of Lactate/Pyruvate compared to contra-lateral brain and Lactate/Bicarbonate similar to the value in contra-lateral brain. Subsequent biopsy of the contrast-enhancing lesion indicated treatment effect.

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