Over the past two decades cardiac BOLD MRI has seen major technical advances. However, its reliability for detecting ischemic heart disease remains poor. We hypothesized that the reliability of cardiac BOLD MRI can be improved by repeatedly acquiring BOLD images following regadenoson injection. We found that repeatedly acquired myocardial BOLD imaging following regadenoson administration can be used to significantly amplify the BOLD sensitivity and improve the reliability of myocardial BOLD MRI in health and disease.
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