Abstract #0497

Function versus occupancy in the human brain: PET/fMRI during infusion of D2 antagonist

Tracy Barbour^1,2, Christin Sander^3,4, Daphne J. Holt^1,5, and Joseph Mandeville^3,4

¹Psychiatry, Massachusetts General Hospital and Athinoula A. Martinos Center for Biomedical Imaging, Boston, MA, United States, ²Harvard Medical School, Boston, MA, United States, ³Radiology, Massachusetts General Hospital and Athinoula A. Martinos Center for Biomedical Imaging, Boston, MA, United States, ⁴Radiology, Harvard Medical School, Boston, MA, United States, ⁵Psychiatry, Harvard Medical School, Boston, MA, United States

Simultaneous PET and fMRI were employed in healthy human subjects to investigate the dose-dependent relationship between drug occupancies of a D2-receptor antagonist and induced CBF responses measured by arterial spin labeling. Results indicate a super-linear relationship between CBF and occupancy, with a larger CBF response in putamen than in caudate at matched occupancies. These results inform dopaminergic neurophysiology, and the method may provide general utility for probing dopaminergic function in human subject cohorts.

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