Abstract #0461

Fibre orientation dispersion in the corpus callosum relates to interhemispheric functional connectivity

Jeroen Mollink^1,2, Saad Jbabdi¹, Stephen M Smith¹, Fidel Alfaro-Almagro¹, Michiel Kleinnijenhuis¹, Anne-Marie van Cappellen van Walsum², and Karla Loreen Miller¹

¹FMRIB centre, University of Oxford, Oxford, United Kingdom, ²Department of Anatomy, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, Netherlands

Fibre orientation dispersion was previously demonstrated to be higher at the center compared to lateral aspects of the corpus callosum (CC) using microscopy data and diffusion MRI data. We hypothesize that this pattern of dispersion in the CC relates to the degree of heterotopic connections in the brain. In a large cohort of 4903 subjects from the Biobank UK, resting-state functional MRI and diffusion MRI data were compared against each other to find associations between fibre dispersion and functional interhemispheric connectivity

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