We have previously shown that hemodynamic signals can be directly detected from individual arterioles and venules penetrating the cortex. Here, the temporal correlation patterns of the vessel-specific hemodynamic signal are characterized in both rodent and human brains. At the resting state, the blood-oxygen-level-dependent (BOLD) signal from venules and the cerebral blood volume (CBV) signal from arterioles show large-scale vessel-specific correlation patterns in rats under anesthesia. Similarly, in awake human subjects, the BOLD hemodynamic signal correlated at the sulcus veins (3T), as well as at a few intra-cortical veins detected at 9.4T, showing vessel-specific activity and connectivity patterns with slow-frequency oscillation up to 0.1Hz.
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