Quantitative Free-Breathing Dynamic Contrast-enhanced MRI in Hepatocellular Carcinoma Using Gd-EOB-DTPA：Correlations With Ki67 Proliferation Status and Histological Grades

This study aims to validate a free-breathing DCE-MRI in HCC patients using gadoxetic acid, and to determine the relationship between DCE-MRI parameters and histological results. Perfusion parameters (K^trans, K_ep, V_e and iAUC) from 34 patients were compared with CT results and correlated with Ki67 indices and the histological grades of HCC. Significant relationship was found between DCE-MRI and CT results, indicating the validity of this protocol in evaluating the vascular change of HCC. The DCE-MRI derived K^trans and iAUC were significantly correlated with the histological grades of HCC, suggesting the potential of those parameters in predicting the malignancy of tumors.