Abstract #0415

Improved Visualization of the Spinal Cord Lesions in Multiple Sclerosis using MP2RAGE at 3T

Jennifer A. Lefeuvre^1,2, Sunil Patil³, Gunnar Krueger⁴, Tobias Kober^5,6,7, Stéphane Lehéricy², Daniel S. Reich¹, and Govind Nair¹

¹TNS/NIB/NINDS, National Institutes of Health, Bethesda, MD, United States, ²CENIR, UPMC-Inserm U1127, CNRS 7225, Institut Cerveau Moelle, Paris, France, ³HC NAM USA DI MR COLLAB, Siemens Medical Solutions, Bethesda, MD, United States, ⁴HC NAM USA DI MR COLLAB, Siemens Medical Solutions, Boston, MA, United States, ⁵Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, ⁶Department of Radiology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland, ⁷Signal Processing Laboratory (LTS 5), Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

Spinal cord lesions are known to be prevalent and contribute to disability in multiple sclerosis (MS). We explored the use of the MP2RAGE sequence for better delineation of spinal cord lesions in a clinical setting, and compared it with standard sequences used in MS. A more accurate measurement of lesion load and better visualization of the lesion location within the spinal cord can help improving MS diagnosis and may be developed to an imaging biomarker of disease burden.

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